Organic Intermediate: formamide

1.Used as an analytical reagent, solvent, and softener, as well as in organic synthesis
2.Used as a raw material for synthesizing imidazole, pyrimidine, 1,3,5-triazine, caffeine, as well as a solvent for spinning acrylonitrile copolymer and anti-static coating of plastic products
3.Formamide has active reactivity and special solubility, and can be used as an organic synthesis raw material, paper processing agent, softener for fiber industry, softener for animal glue, and analytical reagent for determining amino acid content in rice. In organic synthesis, the majority of applications are in medicine, as well as in pesticides, dyes, pigments, spices, and additives. It is also an excellent organic solvent, mainly used in the spinning of acrylonitrile copolymers and ion exchange resins, as well as in the anti-static or conductive coating of plastic products. In addition, it is also used for separating chlorosilane, purifying oils, etc. Formamide can undergo various reactions, including dehydration, CO removal, introduction of amino groups, introduction of acyl groups, and cyclization, in addition to involving three hydrogen atoms. Take Huanhe as an example. Diethyl malonate cyclizes with formamide to obtain the intermediate 4,6-dihydroxypyrimidine of vitamin B4. O-aminobenzoic acid cyclizes with amide to obtain the intermediate quinazolone 4, which is an antiarrhythmic pyrroline. 3-Amino-4-ethoxycarbonyl pyrazole cyclizes with formamide to obtain xanthine oxidase inhibitor allopurinol. Ethylene diamine tetraacetic acid cyclizes with formamide to obtain the anticancer drug ethylimine. The intermediate of sulfonamide drugs, 5-methoxy-4,6-dihydroxypyrimidine disodium, is obtained by cyclization of methoxymethyl malonate with formamide.
4.Ionization solvent. Paper chromatography developer. A softener for animal glue. A softening agent for the fiber industry. Manufacturing formates and hydrocyanic acid.